It is recommend that you use a minimum of 2-3 bottles of Environ™ Vita-Peptide C-Quence Serum 2 before progressing to Vita-Peptide C-Quence Serum 3. Vita-Peptide C-Quence 1-4 Serums are formulated to be used together with Antioxidant Defence Crème. Use with Hydra-Intense Cleansing Lotion, Vita-Peptide Toner and Antioxidant Defence Crème. Faster results can be obtained when used in conjunction with Environ’s™ home skin needling kits, Cosmetic Roll-CIT™, Gold Roll-CIT™ or Focus-CIT™.